Bioinformatics analysis of chimerism in monochorionic dizygotic twins

We conducted a bioinformatics analysis of hematopoietic chimerism of the monochorionic dizygotic twins. Whole-genome sequencing was used to understand the genomic compositions of the chimeras.

Type: Other
Archiver: European Genome-Phenome Archive (EGA)

1 Dataset 2 Publications

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Dataset ID	Description	Technology	Samples
EGAD00001009508	We conducted whole-genome sequencing on blood and buccal specimen from a family with chimerism identified in the two monochorionic dizygotic twins. Blood DNA was obtained from all family members. In addition, we obtained buccal specimen from the chimeric twins. Whole-genome sequencing was conducted on Illumina NovaSeq.	Illumina NovaSeq 6000	8

Publications	Citations
Estimation of intrafamilial DNA contamination in family trio genome sequencing using deviation from Mendelian inheritance. Yoon CJ, Kim SY, Nam CH, Lee J, Park JW, Mun J, Park S, Lee S, Yi B, Min KI, Wiley B, Bolton KL, Lee JH, Kim E, Yoo HJ, Jun JK, Choi JS, Griffith M, Griffith OL, Ju YS. Genome Res 32: 2022 2134-2144	2
Whole-genome sequences reveal zygotic composition in chimeric twins. Yoon CJ, Nam CH, Kim T, Lee JS, Kim R, Yi K, Koh JY, Kim J, Won H, Oh JW, Griffith OL, Griffith M, Sung J, Kim TY, Cho D, Choi JS, Ju YS. HGG Adv 5: 2024 100301	0