The evolutionary dynamics of human colorectal cancer using single-gland spatial multi-omic profiling of DNA, RNA and chromatin.

Deciphering the mechanisms of colorectal cancer growth, progression and dissemination in each individual patient.

3 Datasets 3 Publications

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD00001007828	661 bam files generated from high-throughput RNAseq of tumour biopsies from colorectal cancer patients	NextSeq 500	661
EGAD00001008140	ATAC-seq profiling bam files from colorectal carcinoma and adenoma.	NextSeq 500	1207
EGAD00001008642	WGS profiling bam files from colorectal carcinoma and adenoma.	Illumina NovaSeq 6000	527

Publications	Citations
The co-evolution of the genome and epigenome in colorectal cancer. Heide T, Househam J, Cresswell GD, Spiteri I, Lynn C, Mossner M, Kimberley C, Fernandez-Mateos J, Chen B, Zapata L, James C, Barozzi I, Chkhaidze K, Nichol D, Gunasri V, Berner A, Schmidt M, Lakatos E, Baker AM, Costa H, Mitchinson M, Piazza R, Jansen M, Caravagna G, Ramazzotti D, Shibata D, Bridgewater J, Rodriguez-Justo M, Magnani L, Graham TA, Sottoriva A. Nature 611: 2022 733-743	30
Phenotypic plasticity and genetic control in colorectal cancer evolution. Househam J, Heide T, Cresswell GD, Spiteri I, Kimberley C, Zapata L, Lynn C, James C, Mossner M, Fernandez-Mateos J, Vinceti A, Baker AM, Gabbutt C, Berner A, Schmidt M, Chen B, Lakatos E, Gunasri V, Nichol D, Costa H, Mitchinson M, Ramazzotti D, Werner B, Iorio F, Jansen M, Caravagna G, Barnes CP, Shibata D, Bridgewater J, Rodriguez-Justo M, Magnani L, Sottoriva A, Graham TA. Nature 611: 2022 744-753	40
Contribution of pks<sup>+</sup> E. coli mutations to colorectal carcinogenesis. Chen B, Ramazzotti D, Heide T, Spiteri I, Fernandez-Mateos J, James C, Magnani L, Graham TA, Sottoriva A. Nat Commun 14: 2023 7827	4