WES of clonally related neuroblastoma and teratoma

Mature teratomas are usually benign tumors that rarely undergo malignant transformation. We report an advanced neuroblastoma arising in a mature teratoma of the ovary. Whole-exome sequencing identified extensive copy-neutral LOH in both neuroblastoma and teratoma elements, suggesting that the neuroblastoma evolved from the teratoma.

Type: Other
Archiver: European Genome-Phenome Archive (EGA)

1 Dataset 1 Publication

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Dataset ID	Description	Technology	Samples
EGAD00001007039	This dataset includes bam files of WES of clonally related neuroblastoma and teratoma as well as peripheral blood samples as a control. Neuroblastoma and teratoma samples were formalin-fixed paraffin embedded.	Illumina HiSeq 2500	3

Publications	Citations
Clonal evidence for the development of neuroblastoma with extensive copy-neutral loss of heterozygosity arising in a mature teratoma. Ono R, Ueno H, Yoshida K, Takahashi S, Yoshihara H, Nozaki T, Suzuki K, Nakazawa A, Saiki R, Seki M, Takita J, Ogawa S, Manabe A, Hasegawa D. Cancer Sci 112: 2021 2921-2927	2