Epitope-linked Ig-seq of self-reactive plasma cells in celiac disease

1 Dataset 1 Publication

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Dataset ID	Description	Technology	Samples
EGAD00001005029	Paired immunoglobulin heavy and light chain sequences were obtained from 803 single IgA plasma cells isolated from duodenal biopsies of five celiac disease patients. The cells were specific to discrete antigenic regions of the enzyme TG2, which is the main autoantigen in celiac disease.	Illumina MiSeq	10

Publications	Citations
Efficient T cell-B cell collaboration guides autoantibody epitope bias and onset of celiac disease. Iversen R, Roy B, Stamnaes J, Høydahl LS, Hnida K, Neumann RS, Korponay-Szabó IR, Lundin KEA, Sollid LM. Proc Natl Acad Sci U S A 116: 2019 15134-15139	27