Fibroblast heterogeneity and immunosuppressive environment in Human breast cancer

Carcinoma-associated fibroblasts (CAF) are key players in the tumor microenvironment. Here, by combining 6 well-known stromal markers, we identify four CAF subsets (CAF-S1 to CAF-S4) in human breast cancer (BC) that exhibit distinct activation patterns and accumulate differently in BC subtypes.

Type: Other
Archiver: European Genome-Phenome Archive (EGA)

1 Dataset 5 Publications

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD00001003808	None	Illumina HiSeq 2500	47

Publications	Citations
A subset of activated fibroblasts is associated with distant relapse in early luminal breast cancer. Bonneau C, Eliès A, Kieffer Y, Bourachot B, Ladoire S, Pelon F, Hequet D, Guinebretière JM, Blanchet C, Vincent-Salomon A, Rouzier R, Mechta-Grigoriou F. Breast Cancer Res 22: 2020 76	34
Dissection of intercellular communication using the transcriptome-based framework ICELLNET. Noël F, Massenet-Regad L, Carmi-Levy I, Cappuccio A, Grandclaudon M, Trichot C, Kieffer Y, Mechta-Grigoriou F, Soumelis V. Nat Commun 12: 2021 1089	82
The tumor microenvironment and triple-negative breast cancer aggressiveness: shedding light on mechanisms and targeting. Furukawa N, Stearns V, Santa-Maria CA, Popel AS. Expert Opin Ther Targets 26: 2022 1041-1056	2
Microenvironmental Snail1-induced immunosuppression promotes melanoma growth. Arumi-Planas M, Rodriguez-Baena FJ, Cabello-Torres F, Gracia F, Lopez-Blau C, Nieto MA, Sanchez-Laorden B. Oncogene 42: 2023 2659-2672	2
Hybrid computational modeling highlights reverse warburg effect in breast cancer-associated fibroblasts. Aghakhani S, Silva-Saffar SE, Soliman S, Niarakis A. Comput Struct Biotechnol J 21: 2023 4196-4206	3