Colorectal_organoids_and_tumour_tissue - EGA European Genome-Phenome Archive

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD00001001447	Whole genome sequencing of single cell derived organoids from normal colon tissue and colorectal cancer.	HiSeq X Ten	73

Publications	Citations
Tissue-specific mutation accumulation in human adult stem cells during life. Blokzijl F, de Ligt J, Jager M, Sasselli V, Roerink S, Sasaki N, Huch M, Boymans S, Kuijk E, Prins P, Nijman IJ, Martincorena I, Mokry M, Wiegerinck CL, Middendorp S, Sato T, Schwank G, Nieuwenhuis EE, Verstegen MM, van der Laan LJ, de Jonge J, IJzermans JN, Vries RG, van de Wetering M, Stratton MR, Clevers H, Cuppen E, van Boxtel R. Nature 538: 2016 260-264	503
Use of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancer. Drost J, van Boxtel R, Blokzijl F, Mizutani T, Sasaki N, Sasselli V, de Ligt J, Behjati S, Grolleman JE, van Wezel T, Nik-Zainal S, Kuiper RP, Cuppen E, Clevers H. Science 358: 2017 234-238	220
The mutational impact of culturing human pluripotent and adult stem cells. Kuijk E, Jager M, van der Roest B, Locati MD, Van Hoeck A, Korzelius J, Janssen R, Besselink N, Boymans S, van Boxtel R, Cuppen E. Nat Commun 11: 2020 2493	51
Human induced pluripotent stem cells display a similar mutation burden as embryonic pluripotent cells <i>in vivo</i>. Hasaart KAL, Manders F, Ubels J, Verheul M, van Roosmalen MJ, Groenen NM, Oka R, Kuijk E, Lopes SMCS, Boxtel RV. iScience 25: 2022 103736	5
Common anti-cancer therapies induce somatic mutations in stem cells of healthy tissue. Kuijk E, Kranenburg O, Cuppen E, Van Hoeck A. Nat Commun 13: 2022 5915	5
Mutation accumulation in mtDNA of cancers resembles mutagenesis in normal stem cells. Manders F, van Dinter J, van Boxtel R. iScience 25: 2022 105610	1
Patient-derived organoids (PDOs) and PDO-derived xenografts (PDOXs): New opportunities in establishing faithful pre-clinical cancer models. Wang E, Xiang K, Zhang Y, Wang XF. J Natl Cancer Cent 2: 2022 263-276	0