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Amplicon-based sequencing of drug resistant lung cancer cell lines (2017-07-05)

A EGFR mutant NSCLC cell line which is sensitive to AZD9291 inhibition was mutagenised with the chemical mutagen ENU and then drug selected using a AZD9291. Single cell derived colonies were then manually picked and expanded in drug. Resistance was confirmed in a 14 day assay and DNA was collected. These then underwent targeted amplicon-based sequencing to confirm candidate resistance effectors hypothesised from currently available literature. This dataset contains all the data available for this study on 2017-07-05.

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Wellcome Trust Sanger Institute Cancer Genome Group Data Sharing Policy

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS00001001675 Cancer Genomics

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF00001305538 cram 9.9 MB
EGAF00001305539 cram 10.3 MB
EGAF00001305540 cram 10.5 MB
EGAF00001305541 cram 10.7 MB
EGAF00001305542 cram 12.0 MB
EGAF00001305543 cram 5.1 MB
EGAF00001305544 cram 2.5 MB
EGAF00001305545 cram 17.6 MB
EGAF00001305546 cram 1.9 MB
EGAF00001305547 cram 7.8 MB
EGAF00001305548 cram 3.0 MB
EGAF00001305549 cram 12.0 MB
EGAF00001305550 cram 7.2 MB
EGAF00001305551 cram 11.5 MB
EGAF00001305552 cram 7.3 MB
EGAF00001305553 cram 2.7 MB
EGAF00001305554 cram 13.4 MB
EGAF00001305555 cram 11.0 MB
EGAF00001305556 cram 7.7 MB
EGAF00001305557 cram 11.3 MB
EGAF00001305558 cram 2.6 MB
EGAF00001305559 cram 7.4 MB
EGAF00001305560 cram 8.2 MB
EGAF00001305561 cram 11.9 MB
EGAF00001305562 cram 7.8 MB
EGAF00001306435 cram 9.3 MB
EGAF00001306436 cram 6.0 MB
EGAF00001306437 cram 14.4 MB
EGAF00001306438 cram 7.6 MB
EGAF00001306439 cram 7.7 MB
EGAF00001306440 cram 9.2 MB
EGAF00001306441 cram 7.4 MB
EGAF00001306442 cram 11.1 MB
EGAF00001306443 cram 15.1 MB
EGAF00001306444 cram 3.5 MB
EGAF00001306445 cram 15.1 MB
EGAF00001306446 cram 3.4 MB
EGAF00001306447 cram 10.5 MB
EGAF00001306448 cram 10.5 MB
EGAF00001306449 cram 11.2 MB
EGAF00001306450 cram 6.0 MB
EGAF00001306451 cram 2.8 MB
EGAF00001306452 cram 3.9 MB
EGAF00001306453 cram 3.2 MB
EGAF00001306454 cram 3.3 MB
EGAF00001306455 cram 3.7 MB
EGAF00001306456 cram 4.2 MB
EGAF00001306457 cram 6.8 MB
EGAF00001306458 cram 4.4 MB
EGAF00001306459 cram 4.1 MB
EGAF00001306460 cram 4.2 MB
EGAF00001306461 cram 3.6 MB
EGAF00001306462 cram 3.8 MB
EGAF00001306463 cram 4.0 MB
EGAF00001306464 cram 4.0 MB
EGAF00001306465 cram 3.1 MB
EGAF00001306466 cram 3.5 MB
EGAF00001306467 cram 4.4 MB
EGAF00001306468 cram 2.7 MB
EGAF00001306469 cram 4.2 MB
EGAF00001306470 cram 3.7 MB
EGAF00001306471 cram 4.4 MB
EGAF00001306472 cram 3.6 MB
EGAF00001306473 cram 2.7 MB
EGAF00001306474 cram 991.3 kB
EGAF00001306475 cram 2.9 MB
EGAF00001306476 cram 3.5 MB
EGAF00001306477 cram 4.6 MB
EGAF00001306478 cram 2.4 MB
EGAF00001306479 cram 3.0 MB
EGAF00001306480 cram 3.0 MB
EGAF00001306481 cram 3.0 MB
EGAF00001306482 cram 4.3 MB
EGAF00001306483 cram 4.1 MB
EGAF00001306484 cram 4.7 MB
EGAF00001306485 cram 5.7 MB
EGAF00001306486 cram 3.9 MB
EGAF00001306487 cram 3.4 MB
EGAF00001306488 cram 4.8 MB
EGAF00001306489 cram 4.2 MB
EGAF00001306490 cram 5.5 MB
EGAF00001306491 cram 3.8 MB
EGAF00001306492 cram 3.3 MB
EGAF00001306493 cram 4.9 MB
EGAF00001306494 cram 3.9 MB
EGAF00001306495 cram 3.7 MB
EGAF00001306496 cram 4.6 MB
EGAF00001306497 cram 4.9 MB
EGAF00001306498 cram 6.0 MB
EGAF00001306499 cram 598.2 kB
EGAF00001306500 cram 4.4 MB
EGAF00001306501 cram 4.5 MB
EGAF00001306502 cram 6.1 MB
EGAF00001306503 cram 8.2 MB
EGAF00001306504 cram 6.2 MB
EGAF00001306505 cram 4.4 MB
EGAF00001306506 cram 22.4 MB
EGAF00001306507 cram 5.3 MB
EGAF00001306508 cram 3.0 MB
EGAF00001306509 cram 2.1 MB
EGAF00001306510 cram 3.6 MB
EGAF00001306511 cram 2.8 MB
EGAF00001306512 cram 5.7 MB
EGAF00001306513 cram 12.2 MB
EGAF00001306514 cram 564.3 kB
EGAF00001306515 cram 1.7 MB
EGAF00001306516 cram 10.3 MB
EGAF00001306517 cram 4.2 MB
EGAF00001306518 cram 1.2 MB
EGAF00001306519 cram 2.0 MB
EGAF00001306520 cram 3.0 MB
EGAF00001306521 cram 21.0 MB
EGAF00001306522 cram 4.2 MB
EGAF00001306523 cram 18.1 MB
EGAF00001306524 cram 6.8 MB
EGAF00001306525 cram 7.2 MB
EGAF00001306526 cram 688.7 kB
EGAF00001306527 cram 14.9 MB
EGAF00001306528 cram 14.9 MB
EGAF00001307313 cram 12.2 MB
EGAF00001307314 cram 23.4 MB
EGAF00001307315 cram 15.7 MB
EGAF00001307316 cram 4.5 MB
EGAF00001307317 cram 11.4 MB
EGAF00001307318 cram 11.6 MB
EGAF00001307319 cram 2.1 MB
EGAF00001307320 cram 8.1 MB
EGAF00001307321 cram 18.6 MB
EGAF00001307322 cram 18.6 MB
EGAF00001307323 cram 12.1 MB
EGAF00001307324 cram 2.6 MB
EGAF00001307325 cram 9.9 MB
EGAF00001307326 cram 10.9 MB
EGAF00001307327 cram 22.2 MB
EGAF00001307328 cram 8.3 MB
EGAF00001307329 cram 3.5 MB
EGAF00001307330 cram 22.4 MB
EGAF00001307331 cram 7.4 MB
EGAF00001307332 cram 6.3 MB
EGAF00001307333 cram 884.3 kB
EGAF00001307334 cram 2.2 MB
EGAF00001307335 cram 4.1 MB
EGAF00001307336 cram 3.4 MB
EGAF00001307337 cram 4.0 MB
EGAF00001307338 cram 7.4 MB
EGAF00001307339 cram 2.6 MB
EGAF00001307340 cram 3.9 MB
EGAF00001307341 cram 3.3 MB
EGAF00001307342 cram 3.2 MB
EGAF00001307343 cram 3.4 MB
EGAF00001307344 cram 6.5 MB
EGAF00001307345 cram 7.9 MB
EGAF00001307346 cram 7.8 MB
EGAF00001307347 cram 3.3 MB
EGAF00001307348 cram 4.4 MB
EGAF00001307349 cram 3.5 MB
EGAF00001307350 cram 2.3 MB
EGAF00001307351 cram 3.2 MB
EGAF00001307352 cram 813.7 kB
EGAF00001307353 cram 20.2 MB
EGAF00001307354 cram 4.5 MB
EGAF00001307355 cram 2.1 MB
EGAF00001307356 cram 2.1 MB
EGAF00001307357 cram 2.7 MB
EGAF00001307358 cram 2.6 MB
EGAF00001307359 cram 4.0 MB
EGAF00001307360 cram 2.5 MB
EGAF00001307361 cram 4.4 MB
EGAF00001307362 cram 4.8 MB
EGAF00001307363 cram 8.1 MB
EGAF00001307364 cram 3.4 MB
EGAF00001307365 cram 3.7 MB
EGAF00001307366 cram 8.4 MB
EGAF00001307367 cram 4.1 MB
EGAF00001590352 cram 32.5 MB
EGAF00001590353 cram 18.6 MB
EGAF00001590354 cram 5.0 MB
177 Files (1.2 GB)