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Identification of drug resistance genes in cancer cell lines by insertional mutagenesis

Our aim is to identify genes involved in resistance to anti-cancer therapies. In order to do this we have taken advantage of a lentiviral vector (LV)-based insertional mutagen to mutagenize cancer cell lines. LV-transduced cell lines were then treated with anti-cancer therapies and the emergence of resistant clones scored. DNA from pools of resistant clones was collected, subjected to custom capture by baits designed against the LV sequence, and then sequenced to identify the LV-genomic junction. We hope that the identification of recurrently targeted genes in resistant cell population will allow us to identify genes that mediate drug resistance.

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Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS00001001035 Cancer Genomics

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF00000684442 cram 175.8 MB
EGAF00000684443 cram 184.8 MB
EGAF00000684444 cram 166.1 MB
EGAF00000684445 cram 155.9 MB
EGAF00000684446 cram 175.8 MB
EGAF00000684447 cram 166.1 MB
EGAF00000684448 cram 84.8 MB
EGAF00000684449 cram 111.9 MB
EGAF00000684450 cram 136.5 MB
EGAF00000684451 cram 146.2 MB
EGAF00000684452 cram 150.6 MB
EGAF00000692044 cram 216.2 MB
EGAF00000692045 cram 234.3 MB
EGAF00000692046 cram 234.6 MB
EGAF00000692047 cram 132.1 MB
EGAF00000692048 cram 389.2 MB
EGAF00000692049 cram 257.9 MB
EGAF00000692050 cram 94.1 MB
EGAF00000692051 cram 111.8 MB
EGAF00000692052 cram 82.5 MB
EGAF00000692053 cram 67.8 MB
EGAF00000836589 cram 1.3 GB
EGAF00000836590 cram 1.4 GB
EGAF00000836591 cram 1.2 GB
EGAF00000836592 cram 1.2 GB
EGAF00000836593 cram 1.3 GB
EGAF00000836594 cram 1.2 GB
EGAF00000836595 cram 610.2 MB
EGAF00000836596 cram 809.2 MB
EGAF00000836597 cram 1.0 GB
EGAF00000836598 cram 1.1 GB
EGAF00000836599 cram 1.1 GB
EGAF00000836600 cram 1.3 GB
EGAF00000836601 cram 1.4 GB
EGAF00000836602 cram 1.3 GB
EGAF00000836603 cram 1.2 GB
EGAF00000836604 cram 1.4 GB
EGAF00000836605 cram 1.2 GB
EGAF00000836606 cram 638.7 MB
EGAF00000836607 cram 842.9 MB
EGAF00000836608 cram 1.1 GB
EGAF00000836609 cram 1.1 GB
EGAF00000836610 cram 1.2 GB
EGAF00000836611 cram 1.6 GB
EGAF00000836612 cram 1.6 GB
EGAF00000836613 cram 1.7 GB
EGAF00000836614 cram 961.1 MB
EGAF00000836615 cram 2.8 GB
EGAF00000836616 cram 1.9 GB
EGAF00000836617 cram 685.4 MB
EGAF00000836618 cram 853.6 MB
EGAF00000836619 cram 618.5 MB
EGAF00000836620 cram 471.4 MB
EGAF00000836621 cram 1.6 GB
EGAF00000836622 cram 1.6 GB
EGAF00000836623 cram 1.7 GB
EGAF00000836624 cram 960.3 MB
EGAF00000836625 cram 2.8 GB
EGAF00000836626 cram 1.9 GB
EGAF00000836627 cram 685.0 MB
EGAF00000836628 cram 852.9 MB
EGAF00000836629 cram 617.8 MB
EGAF00000836630 cram 471.6 MB
EGAF00000836631 cram 201.8 MB
EGAF00000836632 cram 234.5 MB
EGAF00000836633 cram 162.5 MB
EGAF00000836634 cram 184.6 MB
EGAF00000836635 cram 102.9 MB
EGAF00000836636 cram 144.5 MB
EGAF00000836637 cram 102.5 MB
EGAF00000836638 cram 151.2 MB
EGAF00000836639 cram 184.6 MB
EGAF00000836640 cram 136.5 MB
EGAF00000836641 cram 274.5 MB
EGAF00000836642 cram 259.7 MB
EGAF00000836643 cram 193.5 MB
EGAF00000836644 cram 221.8 MB
EGAF00000836645 cram 80.3 MB
EGAF00000836646 cram 102.9 MB
EGAF00000836647 cram 80.2 MB
EGAF00000836648 cram 186.5 MB
EGAF00000836649 cram 219.7 MB
EGAF00000836650 cram 191.2 MB
EGAF00000836651 cram 238.3 MB
EGAF00000836652 cram 278.3 MB
EGAF00000836653 cram 171.9 MB
EGAF00000836654 cram 195.6 MB
EGAF00000836655 cram 78.9 MB
EGAF00000836656 cram 106.2 MB
EGAF00000836657 cram 81.3 MB
EGAF00000836658 cram 158.9 MB
EGAF00000836659 cram 187.9 MB
EGAF00000836660 cram 158.8 MB
EGAF00000836661 cram 205.3 MB
EGAF00000836662 cram 208.3 MB
EGAF00000836663 cram 171.2 MB
EGAF00000836664 cram 201.2 MB
EGAF00000836665 cram 122.6 MB
EGAF00000836666 cram 161.2 MB
EGAF00000836667 cram 119.9 MB
EGAF00000836668 cram 168.8 MB
EGAF00000836669 cram 207.9 MB
EGAF00000836670 cram 149.7 MB
EGAF00000836671 cram 134.2 MB
EGAF00000836672 cram 134.6 MB
EGAF00000836673 cram 119.9 MB
EGAF00000836674 cram 135.3 MB
EGAF00000836675 cram 85.1 MB
EGAF00000836676 cram 111.3 MB
EGAF00000836677 cram 81.6 MB
EGAF00000836678 cram 117.1 MB
EGAF00000836679 cram 140.2 MB
EGAF00000836680 cram 105.0 MB
113 Files (62.4 GB)